Thymosin Beta-4
Thymosin Beta-4 is a 43-amino-acid peptide and the most abundant member of the beta-thymosin family, distinguished by an N-terminally acetylated serine residue. It has the molecular formula C212H350N56O78S, a molecular weight of approximately 4963 g/mol, and CAS number 77591-33-4. Encoded by the TMSB4X gene, it was first isolated from calf thymus tissue in 1981. The peptide binds and sequesters G-actin monomers, regulating actin polymerization in eukaryotic cells. Supplied as a white to off-white lyophilized powder, soluble in water, stored refrigerated at 2–8 °C. This product is strictly for research purposes only.
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+ ENDO PASSEDOverview
Thymosin Beta-4 is a 43-amino-acid peptide encoded by the TMSB4X gene and the most abundant member of the beta-thymosin family. It has the molecular formula C212H350N56O78S, a molecular weight of approximately 4963 g/mol, and CAS number 77591-33-4. The peptide was first isolated from calf thymus tissue in 1981 and has since been studied as a principal G-actin–sequestering protein in mammalian cells.
Structurally, Thymosin Beta-4 carries an N-terminal acetyl group on its serine residue. Its full sequence is Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser. The central LKKTETQ motif is the defining actin-binding domain and has been the focus of in-vitro biochemical characterization.
This product is strictly for research purposes only. Not approved for human or animal use.
PubChem Reference: View compound profile on NIH PubChem
This product is strictly for research purposes only. Not approved for human or animal use.
Key Characteristics
MOLECULAR PROFILE
Formula: C212H350N56O78S
Weight: 4963 g/mol
CAS: 77591-33-4
Structure: 43 amino acid acetylated peptide
PHYSICAL PROPERTIES
Form: White to off-white lyophilized powder
Solubility: Soluble in water
Purity: ≥98% (HPLC)
Storage: Keep refrigerated 36‑46 °F (2‑8 °C)
Size: 10mg, 5mg
SKU: AXIOM-THYMOSIN-BETA-4
Categories: Single Peptides
Tags: Research Chemical
This product is strictly for research purposes only. Not for human or animal consumption.
